Cell membrane, transport and resting potential. Action potential. Synaptic transmission. Sensorial receptors. Striated muscle. Introduction to systems physiology.
- Randall, Burggren, French. Eckert: Animal physiology. Mechanisms and adaptations. Freeman & Company
- Autori Vari. Fisiologia, cellule e sistemi. A cura di D’Angelo e Peres. Edi-Ermes
- Aidley. The Physiology of Excitable Cells. Cambridge University Press
- Nicholls, Martin, Wallace, Fuchs. From Neuron to Brain. Sinauer
- Berne, Levi et al. Physiology. Elsevier Inc.
Learning Objectives
Knolewdge acquired. Molecular and supramolecular mechanisms of the physiological processes in the excitable cells. Physiology of the nervous system. Visceral functions.
Competence acquired. Understanding the relation between physiological parameters in cells and tissues.
Skills acquired (at the end of the course):
Evaluate the methodology necessary to analyse a function at different levels of complexity (molecular, cellular and system). Relate the functions of the various systems in the body.
Prerequisites
Courses to be used as requirements (required and/or recommended)
Chemistry, Physics
Courses required:
Courses recommmended
Teaching Methods
Total hours of the course (including the time spent in attending lectures, seminars, private study, examinations, etc...): 75
Hours reserved to private study and other indivual formative activities: 50
Contact hours for: Lectures (hours): 25
Further information
Office hours:
Wednesday (9:00-12:00)
Type of Assessment
oral examination
Course program
Course Contents (detailed programme). Structure and function of the cell membrane. Passive and active transport across the cell membrane. Osmotic equilibrium, electrochemical equilibrium. Ionic basis of the resting potential: Nerst equation, constant field equation. Ionic basis of the action potential: sodium and potassium conductance as function of membrane potential and time. Cardiac action potential. Electric model of the cell membrane. Propagation of the action potential. Synaptic transmission: chemical and electrical synapses. Synaptic integration. Transduction and processing of signals in sensory receptors. Signal coding. Structure-function relation in striated muscle. Molecular mechanism of force generation. Excitation-contraction coupling. Introduction to the physiology of the circulation, respiration and kidney. Arterial pressure control, body acid-base state and its regulation.